A variant spelling of the common Irish surname Guiry, derived from the Gaelic Ó Giobhair meaning "descendent of Iobhar".
In the 1881 census there were 44 people recorded with the Guire surname, ranking it #27,447 among surnames in the records. By 2016, the modern count was 12, ranked #37,385, down from #27,447 in 1881.
The strongest historical links point to Lanchester (Collierley, Kyo, Billingside, Medomsley, Ebchchester, Benfieldside, Heelyfield, Conside, Durham St Oswald and Manchester. In the modern distribution records, the strongest local clusters include No data.
Across the surname records, the highest recorded count for Guire is 180 in 1861. Compared with 1881, the name has fallen by 72.7%.